EXAMPLESOURCEAUDIT.json

{
  "date": "2026-10-28",
  "case_pairs": 6,
  "synthetic_profiles": 12,
  "sources": [
    {
      "id": "A",
      "title": "Kopp SL et al. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy, fifth edition. *Regional Anesthesia and Pain Medicine*. 2025. [10.1136/rapm-2024-105766](https://doi.org/10.1136/rapm-2024-105766)",
      "doi": "10.1136/rapm-2024-105766",
      "scope": "Drug/dose/route-specific bleeding-risk guidance; no individualized timing supplied here",
      "checked": "See ANESTHESIA_OPTIONS_AND_CASES.md for source title, scope and source-type mapping"
    },
    {
      "id": "K",
      "title": "Lavand'homme PM et al. Pain management after total knee arthroplasty: PROSPECT recommendations. *European Journal of Anaesthesiology*. 2022. [10.1097/EJA.0000000000001691](https://doi.org/10.1097/EJA.0000000000001691)",
      "doi": "10.1097/EJA.0000000000001691",
      "scope": "Unilateral primary TKA analgesia, not every joint or revision operation",
      "checked": "See ANESTHESIA_OPTIONS_AND_CASES.md for source title, scope and source-type mapping"
    },
    {
      "id": "M",
      "title": "Klein AA et al. Recommendations for standards of monitoring during anaesthesia and recovery 2021. *Anaesthesia*. [10.1111/anae.15501](https://doi.org/10.1111/anae.15501)",
      "doi": "10.1111/anae.15501",
      "scope": "UK/Ireland monitoring guidance; jurisdiction and setting matter",
      "checked": "See ANESTHESIA_OPTIONS_AND_CASES.md for source title, scope and source-type mapping"
    },
    {
      "id": "X",
      "title": "Neal JM, Neal EJ, Weinberg GL. ASRA Local Anesthetic Systemic Toxicity checklist: 2020 version. *Regional Anesthesia and Pain Medicine*. 2021. [10.1136/rapm-2020-101986](https://doi.org/10.1136/rapm-2020-101986)",
      "doi": "10.1136/rapm-2020-101986",
      "scope": "Published toxicity response resource, not reproduced or replaced by this guide",
      "checked": "See ANESTHESIA_OPTIONS_AND_CASES.md for source title, scope and source-type mapping"
    },
    {
      "id": "IPACK",
      "title": "Hussain N, Brull R, et al. Does the addition of iPACK to adductor canal block in the presence or absence of periarticular local anesthetic infiltration improve analgesic and functional outcomes following total knee arthroplasty? A systematic review and meta-analysis. Regional Anesthesia and Pain Medicine. 2021;46(8):713-721.",
      "pmid": "33990436",
      "doi": "10.1136/rapm-2021-102705",
      "scope": "iPACK added no benefit when periarticular infiltration was used; without infiltration, pain and function improved but opioid consumption did not fall. Not a technique guide.",
      "checked": "Publisher (rapm.bmj.com) title/volume/pages, article identifier and abstract conclusions; not an exhaustive full-text appraisal"
    },
    {
      "id": "P",
      "title": "Beloeil H et al. Balanced Opioid-free Anesthesia with Dexmedetomidine versus Balanced Anesthesia with Remifentanil. *Anesthesiology*. 2021. [10.1097/ALN.0000000000003725](https://doi.org/10.1097/ALN.0000000000003725)",
      "doi": "10.1097/ALN.0000000000003725",
      "scope": "Major non-cardiac surgery (not a TKA trial); dexmedetomidine-based opioid-free anesthesia was associated with more hypoxemia and bradycardia, so avoiding intraoperative opioids is not assumed to be safer",
      "checked": "See ANESTHESIA_OPTIONS_AND_CASES.md for source title, scope and source-type mapping"
    },
    {
      "id": "LIDO",
      "title": "Foo et al. IV lidocaine consensus (2021)",
      "doi": "10.1111/anae.15270",
      "scope": "High-risk IV use, ideal-body-weight context and avoidance of overlapping local-anesthetic interventions; not a complete regimen.",
      "checked": "Publisher/PubMed identity and available source text; not an exhaustive full-text appraisal"
    },
    {
      "id": "DEX",
      "title": "Weerink et al. Dexmedetomidine pharmacology review (2017)",
      "doi": "10.1007/s40262-017-0507-7",
      "scope": "Dose contexts differ by indication; toy-model values are not validated by this review.",
      "checked": "Publisher/PubMed identity and available source text; not an exhaustive full-text appraisal"
    },
    {
      "id": "QOR",
      "title": "Stark et al. Development and psychometric evaluation of the QoR-15 (2013)",
      "doi": "10.1097/ALN.0b013e318289b84b",
      "scope": "Recovery is multidimensional; do not reproduce the questionnaire or interpret a synthetic score as validation.",
      "checked": "Publisher/PubMed identity and available source text; not an exhaustive full-text appraisal"
    }
  ],
  "cases": [
    {
      "id": "TK-01",
      "topic": "Spinal versus general anesthesia",
      "sources": [
        "A",
        "K",
        "M"
      ]
    },
    {
      "id": "TK-02",
      "topic": "Regional analgesia and background regimen",
      "sources": [
        "K",
        "IPACK"
      ]
    },
    {
      "id": "TK-03",
      "topic": "Nonopioid adjuncts are not a mandatory cocktail",
      "sources": [
        "K",
        "P",
        "LIDO",
        "DEX"
      ]
    },
    {
      "id": "TK-04",
      "topic": "Chronic opioid exposure and rescue",
      "sources": [
        "K",
        "P"
      ]
    },
    {
      "id": "TK-05",
      "topic": "Patient-reported outcomes and interpretation",
      "sources": [
        "K",
        "QOR"
      ]
    },
    {
      "id": "TK-06",
      "topic": "Recovery and safe communication",
      "sources": [
        "M",
        "K",
        "X"
      ]
    }
  ],
  "source_identity_checked": true,
  "full_text_audit_complete": false,
  "clinical_validation": false
}